PHARMACOLOGICAL STUDIES ON DERIVATIVES OF CYTOSINE

Abstract

The Schiff bases of cytosine (I) 4-((2-hydroxy-3,5- diiodobenzylidene)amino) pyrimidin-2(1H)-one, (II) 4-((4-hydroxy-3-methoxybenzylidene) amino) pyrimidin-2(1H)-one, (III) 4-((3,4,5-trimethoxybenzylidene)amino) pyrimidin-2(1H)- one, (IV) 4-((furan-2-ylmethylene)amino) pyrimidin-2(1H)-one, (V)  4-((pyridin-4- ylmethylene)amino) pyrimidin-2(1H)-one, (VI) 4-((2-hydroxy-5-nitrobenzylidene)amino) pyrimidin-2(1H)-one, (VII) 4-((4-hydroxy-3-methoxy-5-nitrobenzylidene)amino) pyrimidin- 2(1H)-one and (VIII) 4-((4-(diethylamino)-2-hydroxybenzylidene)amino) pyrimidin-2(1H)- one were prepared and characterized by physical and analytical data, FTIR , 1H NMR, 13C NMR spectra and were screened against gram positive bacteria Staphylococcus aureus,
Basillussubtilis and gram negative bacteria Escherichia Coli, Klebsiellaaerogenes for antibacterial activity and were screened against Aspergillusniger and Candida albicans forantifungal activity by disc diffusion method. Ciprofloxacin and Nystatin were used as standard for bacteria and fungi.